CD124 Primary Antibody
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31844ea_441.jpg?v=1666704680)
![Figure 2:Western blot analysis using CD124 mAb against human CD124 (AA: 26-232) recombinant protein. (Expected MW is 49.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31844rwb_442.jpg?v=1666704680)
![Figure 3:Western blot analysis using CD124 mAb against HEK293 (1) and CD124 (AA: 26-232)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31844twb_443.jpg?v=1666704680)
![Figure 4:Flow cytometric analysis of HL-60 cells using CD124 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31844fcm_444.jpg?v=1666704680)