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CD124 Primary Antibody
|Aliases||IL4R; IL4RA; IL-4RA|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CD124 (AA: 26-232) expressed in E. Coli.|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD124 mAb against human CD124 (AA: 26-232) recombinant protein. (Expected MW is 49.7 kDa)
Figure 3:Western blot analysis using CD124 mAb against HEK293 (1) and CD124 (AA: 26-232)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of HL-60 cells using CD124 mouse mAb (green) and negative control (red).
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
|References (references)||1.Nat Commun. 2017 Jul 14;8:15976. 2.J Cell Sci. 2015 Oct 15;128(20):3781-95.|