CD120B Primary Antibody
Item Information
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Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Product Overview
Immunogen
Purified recombinant fragment of human CD120B (AA: extra 23-257) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using CD120B mAb against human CD120B (AA: extra 23-257) recombinant protein. (Expected MW is 51 kDa)
Western Blot
Figure 3:Western blot analysis using CD120B mAb against HEK293 (1) and CD120B (AA: extra 23-257)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot
Figure 4:Western blot analysis using CD120B mouse mAb against SK-BR-3 (1), C2C12 (2), MOLT4 (3), and T47D (4) cell lysate.
Flow cytometric
Figure 5:Flow cytometric analysis of HL-60 cells using CD120B mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.