CBX3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHECH; HP1-GAMMA; HP1Hs-gamma
ProductOrderC
Clone#6D1C4
Entrez GenelD11335
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CBX3 (AA: 1-183) expressed in E. Coli.
MW20.8kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
full(1-183)
Catalog#: 30823
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Images
Elisa
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot
Figure 2:Western blot analysis using CBX3 mAb against human CBX3 (AA: 1-183) recombinant protein. (Expected MW is 46.8 kDa)
Figure 2:Western blot analysis using CBX3 mAb against human CBX3 (AA: 1-183) recombinant protein. (Expected MW is 46.8 kDa)
Western Blot
Figure 3:Western blot analysis using CBX3 mAb against HEK293 (1) and CBX3 (AA: 1-183)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using CBX3 mAb against HEK293 (1) and CBX3 (AA: 1-183)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of A431 cells using CBX3 mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of A431 cells using CBX3 mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CBX3 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CBX3 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 6:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CBX3 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CBX3 mouse mAb with DAB staining.
Product Overview
DescriptionAt the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
References (references)
References (references)1.BMC Cancer. 2013 Mar 23;13:148.
2.PLoS One. 2012;7(8):e41401.