CBX3 Primary Antibody
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Purified antibody in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 2:Western blot analysis using CBX3 mAb against human CBX3 (AA: 1-183) recombinant protein. (Expected MW is 46.8 kDa)
Figure 3:Western blot analysis using CBX3 mAb against HEK293 (1) and CBX3 (AA: 1-183)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of A431 cells using CBX3 mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CBX3 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CBX3 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.