CBX1 Primary Antibody
|Aliases||CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CBX1 (AA: 1-185) expressed in E. Coli.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 2:Western blot analysis using CBX1 mAb against human CBX1 (AA: 1-185) recombinant protein. (Expected MW is 47.3 kDa)
Figure 3:Western blot analysis using CBX1 mAb against HEK293 (1) and CBX1 (AA: 1-185)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CBX1 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CBX1 mouse mAb with DAB staining.
|Description||This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
|References (references)||1.Endocr Relat Cancer. 2010 May 18;17(2):455-67. |
2.Am J Pathol. 2011 Feb;178(2):672-8.