CBX1 Primary Antibody
Item Information
Catalog #
Size
Price
Description
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Product Overview
Entrez GenelD
10951
Aliases
CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta
Clone#
2B7D6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CBX1 (AA: 1-185) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1.Endocr Relat Cancer. 2010 May 18;17(2):455-67.
2.Am J Pathol. 2011 Feb;178(2):672-8.
2.Am J Pathol. 2011 Feb;178(2):672-8.
Product Image
Elisa
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot
Figure 2:Western blot analysis using CBX1 mAb against human CBX1 (AA: 1-185) recombinant protein. (Expected MW is 47.3 kDa)
Western Blot
Figure 3:Western blot analysis using CBX1 mAb against HEK293 (1) and CBX1 (AA: 1-185)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemical analysis
Figure 4:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CBX1 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CBX1 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.