CBX1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; CBX1
ProductOrderC
Clone#5A3
Entrez GenelD10951
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CBX1 expressed in E. Coli.
MW21kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Monkey
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
N
Catalog#: 20425
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Images
Western Blot
Figure 1: Western blot analysis using CBX1 mouse mAb against Hela (1), COS7 (2), NIH/3T3 (3), A431 (4),and C6 (5) cell lysate.
Figure 1: Western blot analysis using CBX1 mouse mAb against Hela (1), COS7 (2), NIH/3T3 (3), A431 (4),and C6 (5) cell lysate.
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of Hela cells using CBX1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Immunofluorescence analysis of Hela cells using CBX1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 3: Flow cytometric analysis of COS7 cells using CBX1 mouse mAb (green) and negative control (purple).
Figure 3: Flow cytometric analysis of COS7 cells using CBX1 mouse mAb (green) and negative control (purple).
Product Overview
Description

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References (references)
References (references)1. Cell. 2003 Nov 26;115(5):523-35.
2. Cell. 2005 Sep 23;122(6):957-68.
3. Cell. 2006 Nov 3;127(3):635-48.