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CASP6 Primary Antibody
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CASP6 (AA: 194–293) expressed in E. Coli.|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
|(AA: 194–293) expressed in E. Coli.|
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2: Western blot analysis using CASP6 mAb against human CASP6 (AA: 194–293) recombinant protein. (Expected MW is 37.2 kDa)
Figure 3: Western blot analysis using CASP6 mAb against HEK293 (1) and CASP6 (AA: 194–293)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4: Flow cytometric analysis of Hela cells using CASP6 mouse mAb (green) and negative control (red).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
|References (references)||1.Biochemistry. 2017 Aug 29;56(34):4568-4577.
2.Acta Neuropathol Commun. 2016 Dec 8;4(1):127.