BCL-10 Primary Antibody

Item Information
Catalog # Size/Concentration Price
20003 100μl $264.00
Specification
AliasesCLAP; Me10; CIPER; c-E10; CARMEN
Product OrderB
Clone#4F8
Entrez GeneID8915
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human BCL-10 expressed in E. Coli.
MW26kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C.  Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P (Immunohistochemistry) 1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
3-14 (Cys- QSNRELVVDFLS)
Catalog
20003
$264.00
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Images

Western Blot

Cell Culture Products
Figure 1: Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurkat (4) cell lysate.

Immunohistochemical analysis

Cell Culture Products
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 mouse mAb with DAB staining.

Immunofluorescence analysis

Cell Culture Products
Figure 3: Confocal Immunofluorescence analysis of Hela cells using BCL10 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Flow cytometric

Cell Culture Products
Figure 4: Flow cytometric analysis of Hela cells using BCL10 mouse mAb (green) and negative control (purple).
Product Overview
Description Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important
role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other
CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as
upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which
encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to
synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to
the same pathogenetic process that leads to the malignancy.
References (references)
References (references) 1. Willis, T.G., et al. (1999) Cell. 96, 35-45.
2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019.
3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409

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