ATP2C1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHHD; BCPM; PMR1; SPCA1
ProductOrderA
Clone#4G12
Entrez GenelD27032
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of ATP2C1 expressed in E. Coli.
MW100kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Monkey
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
119-269
Catalog#: 30001
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Images
Western Blot
Figure 1: Western blot analysis using ATP2C1 mAb against human ATP2C1 (AA: 119-269) recombinant protein. (Expected MW is 41.7 kDa)
Figure 1: Western blot analysis using ATP2C1 mAb against human ATP2C1 (AA: 119-269) recombinant protein. (Expected MW is 41.7 kDa)
Western Blot
Figure 2: Western blot analysis using ATP2C1 mouse mAb against A431 (1), Hela (2) and HEK293 (3) cell lysate.
Figure 2: Western blot analysis using ATP2C1 mouse mAb against A431 (1), Hela (2) and HEK293 (3) cell lysate.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer (left) and breast cancer (right) tissues using ATP2C1 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer (left) and breast cancer (right) tissues using ATP2C1 mouse mAb with DAB staining.
Product Overview
Description

ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

References (references)
References (references)1. J Invest Dermatol. 2005 Nov;125(5):933-5.
2. J Dermatol Sci. 2006 Aug;43(2):150-1.
3. Dermatology. 2007;215(4):277-83.