ATP2A1 Primary Antibody
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Purified antibody in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using ATP2A1 mAb against human ATP2A1 (AA: 487-631) recombinant protein. (Expected MW is 42 kDa)
Figure 3:Western blot analysis using ATP2A1 mAb against HEK293 (1) and ATP2A1 (AA: 487-631)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Western blot analysis using ATP2A1 mouse mAb against C2C12 (1), COS7 (2), Hela (3), K562 (4), and Jurkat (5) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.