ATM
Item Information
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Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Product Overview
Entrez GenelD
472
Aliases
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Clone#
2A7A10
Host / Isotype
Mouse / Mouse IgG2a
Immunogen
Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4℃; -20℃ for long term storage
Product Applications
IHC_P(Immunohistochemistry)
1/200 - 1/1000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
MC Cancer. 2021 Jan 5;21(1):27.
Fam Cancer. 2022 Apr;21(2):211-227.
Fam Cancer. 2022 Apr;21(2):211-227.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Immunofluorescence analysis
Figure 2:Flow cytometric analysis of Hela cells using ATM mouse mAb (green) and negative control (red).
Immunofluorescence analysis
Figure 3:Flow cytometric analysis of COS-7 cells using ATM mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 4:Immunohistochemical analysis of paraffin-embedded bladder tissues using ATM mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded gastric cancer tissues using ATM mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 6:Immunohistochemical analysis of paraffin-embedded Mouse liver tissues using ATM mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 7:Immunohistochemical analysis of paraffin-embedded Rat kidney tissues using ATM mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 8:Immunohistochemical analysis of paraffin-embedded Rabbit liver tissues using ATM mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.