Sign up for news & promotions:
ASGR2 Primary Antibody
|Aliases||HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human ASGR2 (AA: 80-311) expressed in E. Coli.|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using ASGR2 mAb against human ASGR2 (AA: 80-311) recombinant protein. (Expected MW is 52.5 kDa)
Figure 3:Western blot analysis using ASGR2 mAb against HEK293 (1) and ASGR2 (AA: 80-311)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using ASGR2 mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using ASGR2 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using ASGR2 mouse mAb with DAB staining.
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
|References (references)||1.Mol Cancer Res. 2018 Sep;16(9):1420-1429. 2.PLoS One. 2011;6(11):e27210.|