ARRB1 Primary Antibody
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
2. J Clin Immunol. 2011 Jun;31(3):346-55.
![Figure 1: Western blot analysis using ARRB1 mAb against human ARRB1 (AA: 89-268) recombinant protein. (Expected MW is 46.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30649rwb.jpg?v=1666700585)
![Figure 2: Western blot analysis using ARRB1 mAb against HEK293 (1) and ARRB1 (AA: 89-268)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30649twb.jpg?v=1666700585)
![Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30649ea.jpg?v=1666700585)