ARRB1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesARB1; ARR1
ProductOrderA
Clone#4E11B1
Entrez GenelD408
FormulationPurified antibody in PBS with 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.
MW47kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
89-268
Catalog#: 30649
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using ARRB1 mAb against human ARRB1 (AA: 89-268) recombinant protein. (Expected MW is 46.3 kDa)
Figure 1: Western blot analysis using ARRB1 mAb against human ARRB1 (AA: 89-268) recombinant protein. (Expected MW is 46.3 kDa)
Western Blot
Figure 2: Western blot analysis using ARRB1 mAb against HEK293 (1) and ARRB1 (AA: 89-268)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using ARRB1 mAb against HEK293 (1) and ARRB1 (AA: 89-268)-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

References (references)
References (references)1. J Natl Cancer Inst. 2011 Feb 16;103(4):317-33.
2. J Clin Immunol. 2011 Jun;31(3):346-55.