APC Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesGS; DP2; DP3; BTPS2; DP2.5; PPP1R46
ProductOrderA
Clone#1F7G2
Entrez GenelD324
FormulationPurified antibody in PBS with 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human APC (AA: 2644-2843) expressed in E. Coli.
MW311.6kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
2644-2843
Catalog#: 30669
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Images
Western Blot
Figure 1: Western blot analysis using APC mAb against human APC (AA: 2644-2843) recombinant protein. (Expected MW is 47.4 kDa)
Figure 1: Western blot analysis using APC mAb against human APC (AA: 2644-2843) recombinant protein. (Expected MW is 47.4 kDa)
Western Blot
Figure 2: Western blot analysis using APC mAb against HEK293 (1) and APC (AA: 2644-2843)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using APC mAb against HEK293 (1) and APC (AA: 2644-2843)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 3: Flow cytometric analysis of Hela cells using APC mouse mAb (green) and negative control (red).
Figure 3: Flow cytometric analysis of Hela cells using APC mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

References (references)
References (references)1. Gastroenterology. 2012 Jan;142(1):71-77.
2. Mol Cancer. 2011 Aug 22;10:101.