|Aliases||FDH; FTHFD; 10-fTHF; 10-FTHFDH|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human ALDH1L1 (AA: 10-222) expressed in E. Coli.|
|Species Reactivity||Human, Mouse, Rat|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
|References (references)||1.Chem Biol Interact. 2017 Oct 1;276:23-30.|
2.Oncotarget. 2016 Aug 2;7(31):49397-49410.