Mouse Monoclonal Antibody to CD51

Item Information
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Description

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Product Overview
Entrez GenelD
3685
Aliases
ITGAV; MSK8; VNRA; VTNR
Clone#
3H1A5
Host / Isotype
Mouse / IgG1
Immunogen
Purified recombinant fragment of human CD51 (AA: extra 31-189) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4℃; -20℃ for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.Cancer Lett. 2019 Sep 10;459:204-215. 2.Pathol Res Pract. 2018 Sep;214(9):1352-1355.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using CD51 mAb against human CD51 (AA: extra 31-189) recombinant protein. (Expected MW is 43.6 kDa)
Figure 2:Western blot analysis using CD51 mAb against human CD51 (AA: extra 31-189) recombinant protein. (Expected MW is 43.6 kDa)
Western Blot
Figure 3:Western blot analysis using CD51 mAb against HEK293-6e (1) and CD51 (AA: extra 31-189)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 3:Western blot analysis using CD51 mAb against HEK293-6e (1) and CD51 (AA: extra 31-189)-hIgGFc transfected HEK293-6e (2) cell lysate.
Flow cytometric analysis
Figure 4:Flow cytometric analysis of B16 cells using CD51 mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of B16 cells using CD51 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 32065

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