ROR1-scFv-hinge-TM-CD28-CD3z

ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a type 1 membrane protein that modulates neurite growth in the central nervous system. ROR1 is expressed in a subset of cancers and may facilitate metastasis. ProMab's PM-CAR1103 primary human CAR-T cells express an anti-ROR1 CAR containing a humanized ROR1-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain.