CEA CAR-T cells (CEA scFv-TM-CD28-CD3z)

CEA (carcinoembryonic antigen) is a family of related GPI-linked or transmembrane proteins encoded by the CEACAM genes. CEA is expressed on epithelial cells from healthy and neoplastic gastrointestinal, pulmonary and breast tissue, including most pancreatic adenocarcinomas.

ProMab's PM-CAR1036 primary human CAR-T cells express an anti-CEA CAR containing a CEA-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.