UPK1A CAR-T cells (UPK1A scFv-TM-41BB-CD3z)

UPK1A (uroplakin-1a) is a tetraspanin membrane protein expressed primarily by terminally differentiated urothelial cells in the urinary bladder. UPK1A has been shown to be a diagnostic marker for urothelial carcinoma and may also play a role in muscle-invasive carcinomas.

ProMab's PM-CAR1108 primary human CAR-T cells express an anti-UPK1A CAR containing a UPK1A-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.