PD-L1 CAR-T cells (PDL1 scFv-TM-CD28-CD3z)

PD-L1 (programmed death ligand 1), encoded by the PD1L1 gene, is a type I membrane protein that binds to the checkpoint protein PD-1 on activated T cells, thereby inhibiting T cell activity. Also known as CD274 and B7-H1, PD-L1 is often expressed by cancer cells to promote their escape from immune attack.

ProMab's PM-CAR1045 primary human CAR-T cells express an anti-PD-L1 CAR containing a PD-L1-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.