PD-L1 CAR-T cells (PDL1 scFv-TM-CD28-CD3z)

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Description

PD-L1 (programmed death ligand 1), encoded by the PD1L1 gene, is a type I membrane protein that binds to the checkpoint protein PD-1 on activated T cells, thereby inhibiting T cell activity. Also known as CD274 and B7-H1, PD-L1 is often expressed by cancer cells to promote their escape from immune attack.

 

ProMab's PM-CAR1045 primary human CAR-T cells express an anti-PD-L1 CAR containing a PD-L1-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.

Product Overview
Cell Type Tested
T cells
Formulation
CS10 CryoStor Medium (Sigma Aldrich, Cat, #C2874)
Cell Viability
>90%
Mycoplasma Testing
The cells have been screened using a PCR-based mycoplasma detection kit to confirm the absence of mycoplasma species.
Storage
liquid nitrogen
Shipping & Handing
This product will be shipped in a box containing dry ice at a temperature of -70°C.
For Research Use Only. Not for use in diagnostic procedures.