Mucin-1 CAR-T cells (MUC1 scFv-TM-41BB-CD3z)

MUC1 (mucin short variant S1) is a heavily O-glycosylated type I membrane protein expressed on the apical surface of epithelial cells lining the inner walls of the airway, digestive system, reproductive system and other tissues. MUC1 modulates multiple signaling pathways including ERK, SRC, NF-kB and Ras/MAPK, suggesting a role in tumor-induced changes affecting host immunity. MUC1 is also commonly overexpressed in colon, breast, ovarian, lung and pancreatic cancers.

ProMab's PM-CAR1095 primary human CAR-T cells express an anti-MUC1 CAR containing a MUC1-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.