Mesothelin CAR-T cells (MSLN scFv-FLAG-TM-41BB-CD3z)

Mesothelin, encoded by the MSLN gene, is a GPI-anchored membrane protein expressed on the mesothelium, epithelial cells of mesodermal origin that line body cavities and several organs. Mesothelin is highly upregulated in mesothelioma.

ProMab's PM-CAR1014 primary human CAR-T cells express an anti-mesothelin CAR containing a mesothelin-specific scFv, a FLAG tag, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.