GD2 CAR-T cells (GD2 scFv-TM-41BB-CD3z)

GD2 is a cell membrane-resident disialoganglioside located only in the cerebellum and on peripheral nerves. GD2 is overexpressed in neuroectodermal tumors, including neuroblastoma and melanoma.

ProMab's PM-CAR1094 primary human CAR-T cells express an anti-GD2 CAR containing a GD2-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.