Folate Receptor Alpha (FOLR1 scFv-TM-41BB-CD3z)

FR-alpha (folate receptor alpha), encoded by the FOLR1 gene, is a GPI-linked protein expressed on epithelial cells and upregulated in a number of cancers. FR-alpha binds to folate and folic acid derivates and delivers them to the cell cytoplasm.

ProMab's PM-CAR1078 primary human CAR-T cells express an anti-Folate Receptor Alpha CAR containing an FOLR1-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.