CS1 CAR-T cells (CS1 scFv-TM-CD28-CD3z)

CS1 (CD2 subset-1), encoded by the SLAMF7 gene, is a type 1 membrane protein expressed by NK cells, B cells and plasma cells. CS1 is a homophilic receptor, and CS1-CS1 interactions lead to the activation of NK cell cytotoxicity and B cell proliferation. CS1 is also a marker of malignant plasma cells in multiple myeloma.

ProMab's PM-CAR1057 primary human CAR-T cells express an anti-CS1 CAR containing a CS1-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.