CD70 CAR-T cells (CD70 scFv-TM-41BB-CD3z)

CD70 is a type II membrane protein expressed on activated lymphocytes and mature dendritic cells. On T cells and B cells, CD70 acts as a costimulatory molecule, promoting cell activation, proliferation and survival. CD70 is overexpressed in Hodgkin's and non-Hodgkin's lymphomas, as well as certain types of solid tumors, and correlates with cancer aggressiveness.

ProMab's PM-CAR1074 primary human CAR-T cells express an anti-CD70 CAR containing a CD70-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.