CD47 CAR-T cells (CD47 scFv-TM-CD28-CD3z)
CD47 is a membrane protein expressed by many cell types and involved in a variety of processes including cell adhesion, inflammation, apoptosis and angiogenesis. CD47 is upregulated in many cancers and has been found to inhibit cancer cell phagocytosis by macrophages.
ProMab's PM-CAR1040 primary human CAR-T cells express an anti-CD47 CAR containing a CD47-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.