CD37 CAR-T cells (CD37 scFv-TM-CD28-CD3z)
CD37 is a membrane glycoprotein expressed on normal and neoplastic hematopoietic cells, especially B cells. CD37 is involved in cell adhesion and signal transduction, promoting cell activation and motility.
ProMab's PM-CAR1052 primary human CAR-T cells express an anti-CD37 CAR containing a CD37-specific scFv, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.