CD22 CAR-T cells (CD22 scFv-TF-TM-CD28-CD3z)

CD22 is a type 1 membrane glycoprotein expressed on B cells and B cell cancers. A member of the SIGLEC family of lectins, CD22 mediates cell-cell interactions and regulates B cell activation.

ProMab's PM-CAR1047 primary human CAR-T cells express an anti-CD22 CAR containing a CD22-specific scFv, a TF tag, hinge and transmembrane domains, the CD28 costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. Please inquire for orders over 10 million cells. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.