CD138scFv-FLAG-TM28-CD28-CD3z

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Description

CD138scFv-FLAG-TM28-CD28-CD3z CAR-T cells are generated with a lentivirus expressing CAR from normal human healthy donors. All cells are available at 1x10^6 to 1x10^7 cells in frozen vials, and shipped on dry-ice. For orders larger than >1x10^9, please inquire. CAR-T cells are cryopreserved in next-generation cryopreservation CS10 CryoStor medium (Sigma Aldrich, Catalog Number: C2874). All our cells are pathogen- and mycoplasma- free.

Product Overview
Cell Type Tested
T cells
Formulation
CS10 CryoStor Medium (Sigma Aldrich, Cat, #C2874)
Cell Viability
>90%
Mycoplasma Testing
The cells has been screened using a PCR-based mycoplasma detection kit to conirm the absence of mycoplasma species.
Storage
-80°C; liquid nitrogen
Shipping & Handing
This product will be shipped in a box containing dry ice at a temperature of -70°C.
Product Image
CAR Structure
Figure 1. Schematic representation of the scFv, costimulatory domain, and activation domain of PM-CAR1028. This construct targets CD138. 
Figure 1. Schematic representation of the scFv, costimulatory domain, and activation domain of PM-CAR1028. This construct targets CD138. 
IFN-gamma secretion
Figure 2. CD138-CD28-CD3-CAR-T cells secrete significant level of IFN-gamma (top panel) and IL-2 (bottom panel) against RPMI8226 multiple myeloma target cells. Effector: Target cells ratio=5:1.
Figure 2. CD138-CD28-CD3-CAR-T cells secrete significant level of IFN-gamma (top panel) and IL-2 (bottom panel) against RPMI8226 multiple myeloma target cells. Effector: Target cells ratio=5:1.
For Research Use Only. Not for use in diagnostic procedures.