CA125 CAR-T cells (CA125 scFv-TM-41BB-CD3z)

Item Information

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Description

CA125 is a type I membrane protein expressed on epithelial cells of the respiratory tract and the female reproductive tract as well as on ocular surfaces. Also known as mucin-16, CA-125 is elevated in the plasma of ovarian carcinoma patients and may play a role in metastasis by binding to mesothelin.

ProMab's PM-CAR1093 primary human CAR-T cells express an anti-CA125 CAR containing a CA125-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.

Product Overview

Cell Type Tested

T cells

Formulation

CS10 CryoStor Medium (Sigma Aldrich, Cat, #C2874)

Cell Viability

>90%

Mycoplasma Testing

The cells have been screened using a PCR-based mycoplasma detection kit to confirm the absence of mycoplasma species.

Storage

liquid nitrogen

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