Alpha-Fetoprotein CAR-T cells (AFP scFv-TM-41BB-CD3z)
AFP (alpha-fetoprotein) is a major plasma protein in the fetus, binding to copper, nickel, fatty acids and bilirubin. In adults, alpha-fetoprotein levels are low but can be elevated by hepatocellular carcinoma.
ProMab's PM-CAR1079 primary human CAR-T cells express an anti-Alpha Fetoprotein CAR containing an AFP-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.