MDR1 (PT0531R) PT® Rabbit mAb

Item Information

Catalog #

Size

Price

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],

Product Overview

Entrez GenelD

5243

Clone#

PT0531R

Host / Isotype

Rabbit / IgG, Kappa

Species Reactivity

Human

Formulation

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage

-15°C to -25°C / 1 year (Do not store below -25°C)

Product Applications

WB (Western Blot)

1/2000 - 1/10000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/5000 - 1/20000

Product Image

Human liver was stained with anti-MDR1 (PT0531R) rabbit antibody

Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-MDR1 (PT0531R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: SH-SY5Y Predicted band size: 141kDa Observed band size: 141kDa

For Research Use Only. Not for use in diagnostic procedures.