LRP6 (PT0651R) PT® Rabbit mAb

Item Information

Catalog #

Size

Price

Description

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

Product Overview

Entrez GenelD

4040

Clone#

PT0651R

Host / Isotype

Rabbit / IgG, Kappa

Species Reactivity

Human, Mouse

Formulation

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage

-15°C to -25°C / 1 year (Do not store below -25°C)

Product Applications

WB (Western Blot)

1/2000 - 1/10000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/5000 - 1/20000

Product Image

Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-LRP6 (PT0651R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: Hela Lane 2: Jurkat Lane 3: HEK293 Predicted band size: 180kDa Observed band size: 210kDa