Dnmt1 (PT0542R) PT® Rabbit mAb
Item Information
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Description
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Product Overview
Entrez GenelD
1786
Clone#
PT0542R
Host / Isotype
Rabbit / IgG, Kappa
Species Reactivity
Human, Mouse, Rat
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage
-15°C to -25°C / 1 year (Do not store below -25°C)
Product Applications
WB (Western Blot)
1/2000 - 1/10000
IHC_P(Immunohistochemistry)
1/1000 - 1/4000
ELISA
1/5000 - 1/20000
Product Image
Human tonsil was stained with anti-Dnmt1 (PT0542R) rabbit antibody
Various whole cell lysates were separated by 4-8% SDS-PAGE, and the membrane was blotted with anti-Dnmt1 (PT0542R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Lane 1: Jurkat
Predicted band size: 183kDa
Observed band size: 183kDa
For Research Use Only. Not for use in diagnostic procedures.