CDK4 (PT0399R) PT® Rabbit mAb

Item Information

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Description

cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],

Product Overview

Entrez GenelD

1019

Clone#

PT0399R

Host / Isotype

Rabbit / IgG, Kappa

Species Reactivity

Human, Mouse, Rat

Formulation

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage

-15°C to -25°C / 1 year (Do not store below -25°C)

Product Applications

WB (Western Blot)

1/1000 - 1/5000

ELISA

1/5000 - 1/20000

Product Image

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-CDK4 (PT0399R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: Hela Lane 2: C6 Lane 3: 3T3-L1 Predicted band size: 34kDa Observed band size: 34kDa

For Research Use Only. Not for use in diagnostic procedures.