β Catenin (Phospho Thr41/Ser45) (PT0637R) PT® Rabbit mAb

Item Information

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Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],

Product Overview

Entrez GenelD

1499

Clone#

PT0637R

Host / Isotype

Rabbit / IgG, Kappa

Species Reactivity

Human, Mouse, Rat

Formulation

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage

-15°C to -25°C / 1 year (Do not store below -25°C)

Product Applications

WB (Western Blot)

1/2000 - 1/10000

ELISA

1/5000 - 1/20000

Product Image

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-β Catenin (Phospho Thr41/Ser45) (PT0637R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: SW620 Lane 2: SW480 Predicted band size: 86kDa Observed band size: 92kDa

For Research Use Only. Not for use in diagnostic procedures.