TNNI3 Primary Antibody

Item Information

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Description

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Product Overview

Entrez GenelD

7137

Aliases

CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817; TNNI3

Host / Isotype

Rabbit / IgG

Species Reactivity

Human, Mouse, Rabbit

Immunogen

Synthesized non-phosphopeptide derived from human TNNI3 around the phosphorylation site of serine 22 (R-R-SP-SP-A-N).

Formulation

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

ELISA

1/10000

References

1. J Rheumatol. 2009 Dec;36(12):2711-4.
2. J Biol Chem. 2010 Jan 22;285(4):2686-94.
3. Interact Cardiovasc Thorac Surg. 2010 Mar;10(3):413-6.

Product Image

Western Blot