SP1 Primary Antibody
Item Information
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Description
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated bypost-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage.Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter.
Product Overview
Entrez GenelD
6667
Aliases
TSFP1, Transcription factor SP1, transcription factor Sp1
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from internal of human sp1.
Formulation
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Cancer Res. 2010 Feb 1;70(3):1111-9.
2. Biochem J. 2010 Apr 14;427(3):391-400.
2. Biochem J. 2010 Apr 14;427(3):391-400.
Product Image
Western Blot
Figure 1: Western blot analysis using SP1 Rabbit pAb against SW620 (1) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left), ovarian cancer tissues (right) using SP1 Rabbit pAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.