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RUNX1 Primary Antibody
|Aliases||AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; RUNX1|
|Formulation||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.|
|Immunogen||Synthesized non-phosphopeptide derived from human RUNX1 around the phosphorylation site of serine 435.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|Species Reactivity||Human, Mouse, Rabbit|
Figure 1: Western blot analysis using RUNX1 Rabbit pAb against MOT4 (1), Jurkat (2), HepG2 (3), SW620 (4), MCF-7 (5) and PC-2 (6) cell lysate.
|Description||Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.|
|References (references)||1. Mol Med. 2010 Jul-Aug;16(7-8):247-53.
2. Mol Cell Biol. 2010 Aug;30(16):3943-55.