Ret Primary Antibody

Item Information
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Description

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Product Overview
Entrez GenelD
5979
Aliases
PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1; RET
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from internal of human Ret.
Formulation
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. J Biol Chem. 2010 Jun 11;285(24):18565-74.
2. Hum Mol Genet. 2010 Jul 15;19(14):2804-16.
3. Am J Med Sci. 2010 Jul;340(1):60-3.
Product Image
Western Blot
Figure 1: Western blot analysis using Ret Rabbit pAb against K562 (1) cell lysate.
Figure 1: Western blot analysis using Ret Rabbit pAb against K562 (1) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded hypothyroid tumour using Ret Rabbit pAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded hypothyroid tumour using Ret Rabbit pAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.