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GRB2 Primary Antibody
|Formulation||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.|
|Immunogen||Synthesized peptide derived from internal of human GRB2.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|Species Reactivity||Human, Mouse, Rat|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
Figure 1: Western blot analysis using GRB2 Rabbit pAb against C6 (1), NIH/3T3 (2), A431 (3), MCF-7 (4) and COS7 (5) cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-embedded ovary cancer tumor (left), mammary cancer tissues (right) using GRB2 Rabbit pAb with DAB staining.
|Description||This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.|
|References (references)||1. Am J Pathol. 2009 Apr;174(4):1524-33.
2. J Alzheimers Dis. 2009 Sep 11.