AML1 Primary Antibody

Item Information
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Description

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Product Overview
Entrez GenelD
861
Aliases
AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; RUNX1
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from internal of human AML1.
Formulation
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ICC (Immunocytochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Cancer Treat Res. 2010;145:127-47.
2. Blood. 2010 Jul 15;116(2):254-66.
3. FASEB J. 2010 Sep;24(9):3500-10.
Product Image
Western Blot
Figure 1: Western blot analysis using AML1 Rabbit pAb against Jurkat (1) cell lysate.
Figure 1: Western blot analysis using AML1 Rabbit pAb against Jurkat (1) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left), mammary cancer tissues (right) using AML1 Rabbit pAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left), mammary cancer tissues (right) using AML1 Rabbit pAb with DAB staining.
Immunofluorescence analysis
Figure 3:Immunofluorescence analysis of LOVO cells using AML1 Rabbit pAb (Red).
Figure 3:Immunofluorescence analysis of LOVO cells using AML1 Rabbit pAb (Red).
For Research Use Only. Not for use in diagnostic procedures.