PKD1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPC1; Mflj00285
ProductOrderP
Clone#8C3D11
Entrez GenelD18763
FormulationPurified antibody in PBS with 0.05% sodium azide
HostRat
IsotypeIgG1
ImmunogenPurified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.
MW466kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
Sequence
3682-3873
Catalog#: 30739
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Images
Flow cytometric
Figure 1: Flow cytometric analysis of Hela cells using PKD1 Rat mAb (green) and negative control (red).
Figure 1: Flow cytometric analysis of Hela cells using PKD1 Rat mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
DescriptionInvolved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
References (references)
References (references)FASEB J. 2011 Jul;25(7):2418-32.
PLoS One. 2012;7(9):e46038.
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