PKD1 Primary Antibody
Item Information
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Description
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Product Overview
Entrez GenelD
18763
Aliases
PC1; Mflj00285
Clone#
8C3D11
Host / Isotype
Rat / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
FASEB J. 2011 Jul;25(7):2418-32.
PLoS One. 2012;7(9):e46038.
PLoS One. 2012;7(9):e46038.
Product Image
Flow cytometric
Figure 1: Flow cytometric analysis of Hela cells using PKD1 Rat mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.