ZBTB7B Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesTHPOK; ZFP67; ZBTB15; c-Krox; hcKrox; ZNF857B; DKFZp686G01254; ZBTB7B
ProductOrderZ
Clone#7C12
Entrez GenelD51043
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human ZBTB7B expressed in E. Coli.
MW58kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
384-539
Catalog#: 30011
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Images
Western Blot
Figure 1: Western blot analysis using ZBTB7B mAb against HEK293 (1,2) cell lysate.
Figure 1: Western blot analysis using ZBTB7B mAb against HEK293 (1,2) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Breast tissues using anti-ZBTB7B mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Breast tissues using anti-ZBTB7B mouse mAb
Immunofluorescence analysis
Figure 3: Immunofluorescence analysis of Hela cells using ZBTB7B mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin
Figure 3: Immunofluorescence analysis of Hela cells using ZBTB7B mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin
Product Overview
Description

ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

References (references)
References (references)1.Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6.
2.J Biol Chem. 2000 Sep 1;275(35):27421-38.
3.J Cell Biochem. 2009 Aug 15;107(6):1037-45. Review.