XBP1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesXBP2; TREB5; XBP1
ProductOrderX
Clone#1C4
Entrez GenelD7494
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human XBP1 expressed in E. Coli.
MW28kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
1-160
Catalog#: 30035
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using XBP1 mouse mAb against XBP1(AA: 1-160)-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using XBP1 mouse mAb against XBP1(AA: 1-160)-hIgGFc transfected HEK293 cell lysate.
Product Overview
Description

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

References (references)
References (references)1. J Biol Chem. 2009 May 29;284(22):14904-13.
2. Neoplasia. 2009 May;11(5):436-47.
3. Clin Cancer Res. 2009 Jun 1;15(11):3834-41.