WDR5 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesSWD3; BIG-3; WDR5
ProductOrderW
Clone#7B11
Entrez GenelD11091
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human WDR5 expressed in E. Coli.
MW36.6kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
158-334
Catalog#: 30073
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Images
Western Blot
Figure 1: Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.
Figure 1: Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.
Product Overview
Description

WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

References (references)
References (references)1. Mol Syst Biol. 2007;3:89.
2. J Biol Chem. 2008 Nov 21;283(47):32162-75.