WDR5 Primary Antibody
Item Information
Catalog #
Size
Price
Description
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Product Overview
Entrez GenelD
11091
Aliases
SWD3; BIG-3; WDR5
Clone#
7B11
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human WDR5 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Mol Syst Biol. 2007;3:89.
2. J Biol Chem. 2008 Nov 21;283(47):32162-75.
2. J Biol Chem. 2008 Nov 21;283(47):32162-75.
Product Image
Western Blot
Figure 1: Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.