UBE1L Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesD8; UBE2; UBA1B; UBE1L; MGC12713; UBA7
ProductOrderU
Clone#5B10
Entrez GenelD7318
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human UBE1L expressed in E. Coli.
MW112kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
150-350
Catalog#: 30095
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Images
Western Blot
Figure 1: Western blot analysis using UBE1L mouse mAb against Raji (1) and THP-1 (2) cell lysate.
Figure 1: Western blot analysis using UBE1L mouse mAb against Raji (1) and THP-1 (2) cell lysate.
Product Overview
Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.

References (references)
References (references)1. Cancer Res. 1992 Mar 15;52(6):1536-41
2. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5.
3. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11.