UBE1L Primary Antibody
The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
2. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5.
3. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11.
![Figure 1: Western blot analysis using UBE1L mouse mAb against Raji (1) and THP-1 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30095lwb.jpg?v=1666699085)