TrkA Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesNTRK1, MTC, TRK, TRK1
ProductOrderT
Clone#6B2
Entrez GenelD4914
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
MW87.4kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(33-423)/72.1
Catalog#: 20337
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using TrkA mouse mAb against extracellular domain of human TrkA(aa33-423).
Figure 1: Western blot analysis using TrkA mouse mAb against extracellular domain of human TrkA(aa33-423).
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of PC-12 cells using TrkA mouse mAb (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of PC-12 cells using TrkA mouse mAb (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

References (references)
References (references)1. DNA Repair (Amst). 2008 Oct 1;7(10):1757-64.
2. Traffic. 2008 Jul;9(7):1146-56.