TrkA Primary Antibody

Item Information

Catalog #

Size

Price

Description

TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Product Overview

Entrez GenelD

4914

Aliases

NTRK1, MTC, TRK, TRK1

Clone#

6B2

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Product Applications

WB (Western Blot)

1/500 - 1/2000

ICC (Immunocytochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. DNA Repair (Amst). 2008 Oct 1;7(10):1757-64.
2. Traffic. 2008 Jul;9(7):1146-56.

Product Image

Western Blot

Figure 1: Western blot analysis using TrkA mouse mAb against extracellular domain of human TrkA(aa33-423).

Immunofluorescence analysis

Figure 2: Confocal Immunofluorescence analysis of PC-12 cells using TrkA mouse mAb (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.

For Research Use Only. Not for use in diagnostic procedures.