Mouse Monoclonal Antibody to TRIB2
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/f531923c08b08c40ca185d57e633ee6eb149fb6e9e7e6cda80de4e773049ab2b.jpg?v=1666705913)
![Figure 2:Western blot analysis using TRIB2 mAb against human TRIB2 (AA: 1-200) recombinant protein. (Expected MW is 25.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/3dbfec30c20984f046662e79a8bfe1748bf12807aa3cf3fb60a153805e7ffb82.jpg?v=1666705913)
![Figure 3:Western blot analysis using TRIB2 mAb against HEK293-6e (1) and human TRIB2 (AA: 1-200)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/62a5b6ea80476b6a17bcea45b8401f451fe0a5b1f28f2461c7534fdc40108775.jpg?v=1666705913)
![Figure 4:Flow cytometric analysis of Jurkat cells using TRIB2 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/89341c49f855856f6d5ead9bf7ce5655dc5dabc5aa3af94ef54f0e66bb278c8b.jpg?v=1666705913)
![Figure 5:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using TRIB2 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/5ff733aa3e513fc4920a330b76bc693dc0106e84cbd7e1b91fe87b25ee58795d.jpg?v=1666705913)
![Figure 6:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using TRIB2 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/802be642c7e9abbe3d519f334fc9ab557eda88b651875d030bd6d8ae8339370c.jpg?v=1666705913)
![Figure 7:Immunofluorescence analysis of Hela cells using TRIB2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/08930206094de685034ec54c50eac2c73f020e2fcd1eafbc72695f6aaf15ff25.jpg?v=1666705913)