Mouse Monoclonal Antibody to TRIB2
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/ed4363158c70586076b41b9de7a29fe211074594c6ce9dbbc21c7e706cc58b10.jpg?v=1666705902)
![Figure 2:Western blot analysis using TRIB2 mAb against human TRIB2 (AA: 1-200) recombinant protein. (Expected MW is 25.7 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/7b24e943b5c4cfb50c38c823e3ffd43e7a937aa627511aa0568091ca465d5f28.jpg?v=1666705902)
![Figure 3:Western blot analysis using TRIB2 mAb against HEK293-6e (1) and human TRIB2 (AA: 1-200)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/062c623822e5626805ff89a05491167d15efe52348edef596a0440642b421cfc.jpg?v=1666705902)
![Figure 4:Flow cytometric analysis of Jurkat cells using TRIB2 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/01d2cbe202457855051c6e13fd1a3951333088dff138477d28ee8bc550c606e7.jpg?v=1666705902)
![Figure 5:Immunofluorescence analysis of Hela cells using TRIB2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/1656316b88e437019df2bc283d1dd59ac764440dccdce07073bcfdd8983c112c.jpg?v=1666705902)